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KMID : 1098420040120040304
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Korean Journal of Medicinal Crop Science
2004 Volume.12 No. 4 p.304 ~ p.308
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Immune Activities in Hypericum perforatum L.
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Park JIn-Hong
Kim Dae-Ho
Choi Geun-Pyo
Ryu Lee-Ha
Lee Kang-Yoon
Lee Hyeon-Yong
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Abstract
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Immune enhancing activities of water and ethanol extracts of Hypericum perforatum L. (HP) were examined. HP extracts inhibited the growth of human hepatocarcinoma, human gastric cancer cell and human breast cancer cells in concentration-dependent mammers over a concentration range of 0.05{sim}1.0;mg/ml, showing inhibiton of more than 80% with the concentration of 1.0 mg/ml. However, HP the same concentration. Overall selectivity of the extracts on the three human cancer lines was over 3.5, which is higher than those from the conventional herbs. The growth of human immune B and T cells was enhanced up to 1.4 to 2.0 folds by the addition of the extracts for 4 days, compared to controls. Ethanol extracts of HP after 6 days incubation increased the secretions of tumor necrosis factor-alpha (TNF-{alpha}) from T cells and interleukin-6 (IL-6) from B cells to 6.7 pg/cell and 6.8 pg/cell, respectively. These results suggest that HP has a potent immune enhancing effect.
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KEYWORD
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Hypericum perforatum L., TNF-{alpha}, interleukin-6, immune modulating activities
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